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Crystal Structures of Ceg10 – A labor of Love

Crystal Structure of Ceg10

Today, the crystal structure of Ceg10, an effector protein from Legionella was deposited and released at the RSCB Protein Data Bank (PDB). While a lot remains to be determined about its function and targets during an infection, we are excited to finally release some of what we have learned about this protein in the last 8 years! The Ceg10 crystal structures are part of a collaborative project between Dr. Heisler’s lab and the Gammon, Alto, and Taglialucci lab’s at UT Southwestern Medical School.

More about what Ceg10 does during a viral infection can be found in a recent preprint: Exploiting Bacterial Effector Proteins to Uncover Evolutionarily Conserved Antiviral Host Machinery
The crystal structures can be found at the RSCD PDB: 9B8D and 9B8E

Your 2024 March Madness Winner: Cate

Disclaimer: I don’t really know anything about college basketball…

This was how the bracket was submitted by Cate this year. Yet, somehow she managed to pick more games correctly than anyone else in the lab!

Congrats Cate!

And now what dessert will you be selecting for lab meeting?

New Bracket Leader

Going into the Final 4 match up, Cate has jumped Brianne for most points! Winning is going to come down to who if UCONN or Purdue win more games at this point…

Points Going into the Final Four:
Cate – 71
Brianne – 70
Ryan – 68
Dr. Heisler – 62
Anastasia – 62
Declan – 61
Megan – 55
Elizabeth – 49

Brianne Pulls Away, but loses her Champion

After last nights games and more upsets, the rankings are as follows:

Brianne – 70
Cate – 63
Ryan – 60 
Dr. Heisler – 54 
Declan – 53 
Megan – 47 
Anastasia – 46 
Elizabeth – 41 

With the elimination of UNC and Creighton this last round, Megan and Elizabeth will not be have enough points left to compete for the top spot. However everyone else (even Brianne with having lost UNC) still has a fighting chance with maximal points possible ranging from 165 (Declan) to 102 (Brianne) so its still really anyone’s game.